TLR8 agonist 9

TLR8 agonist9 (Compound II-77) functions as an agonist for Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 ?M. This compound is stable in human and mouse plasma and effectively induces the secretion of the cytokine TNF? with an EC50 of less than 1 ?M. In the MC38-HER2 xenograft mouse model, TLR8 agonist9 demonstrates significant antitumor activity, achieving a tumor growth inhibition (TGI) rate of 97%.