BODIPY-Cyclopamine

Product Specifications

CAS Number

334658-24-1

Target

Others|||Smo

Related Pathways

Others|||Stem Cells

Bioactivity

BODIPY-Cyclopamine is a fluorescent ligand for the Smoothened (SMO) receptor. SMO activation, which is regulated by Patch protein, is linked to tumorigenesis when excessively activated. Using NanoBRET technology, sensitive detection of the resonance energy transfer between SMO and BODIPY-Cyclopamine can be achieved, facilitating high-throughput screening and kinetic analysis. Additionally, studying the binding sites of BODIPY-Cyclopamine on SMO can aid in discovering SMO-targeted drugs.

Smiles

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