GNE7599
Product Specifications
CAS Number
2771069-76-0
Target
Ligand for E3 Ligase
Related Pathways
PROTAC
Bioactivity
GNE7599 is a high-affinity, orally active von Hippel-Lindau (VHL) ligand with a dissociation constant (Kd) of 540 pM. It can be linked via a linker to a protein ligand for the synthesis of PROTAC.
Smiles
[C@@H](C(=O)N1[C@H](C(N[C@@H]2C=3C(=CC(=CC3)C4=C(C)N=CS4)CCCC2)=O)C[C@@H](O)C1)([C@](C)(C)C)N5C=C(N=N5)C6CC6
Molecular Formula
C31H40N6O3S
Molecular Weight
576.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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