Anemoside A3-methyl 6-aminohexanoate
Product Specifications
CAS Number
2919975-48-5
Target
NF-?B
Related Pathways
NF-?B
Bioactivity
Anemoside A3-methyl 6-aminohexanoate (Compound A3-6), a derivative of Pulchinenoside C (Anemoside B4), exhibits potent inhibition of pyruvate carboxylase (PC) with an IC 50 of 0.058 ?M. It also reprograms macrophage function and alleviates DSS-induced colitis by inhibiting the NF-?B and NLRP3 inflammasome pathways. Compared to Anemoside B4, Anemoside A3-methyl 6-aminohexanoate demonstrates moderate in vivo pharmacokinetic properties.
Smiles
C(NCCCCCC(OC)=O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)([C@@](CO)(C)[C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O7)[C@@H](O)[C@@H](O)CO6)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]
Molecular Formula
C48H79NO13
Molecular Weight
878.14
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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