PROTAC FLT-3 degrader 4
Product Specifications
CAS Number
2956722-48-6
Target
Apoptosis, PROTACs, FLT
Related Pathways
Apoptosis, PROTAC, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
PROTACFLT-3degrader 4 is an orally active CRBN-based FLT3-PROTAC degrader that efficiently induces the degradation of FLT3-ITD via the ubiquitin-proteasome system. It demonstrates high selectivity for FLT3-ITD mutant acute myeloid leukemia (AML) cells. [Blue: CRBN ligand, Black: linker; Pink: FLT3 inhibitor].
Smiles
O=C1N(C(=O)C=2C1=CC(=CC2)N3CCC(CN4CCN(CC(NC=5C(C)=C(/C=C\6/C=7C(NC6=O)=CC=C(F)C7)NC5)=O)CC4)CC3)C8C(=O)NC(=O)CC8
Molecular Formula
C39H41FN8O6
Molecular Weight
736.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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