G-5758
Product Specifications
CAS Number
2413455-99-7
Target
IRE1, Liposome
Related Pathways
Metabolism, Cell Cycle/Checkpoint
Bioactivity
G-5758 is an orally active IRE1α inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.
Smiles
O(C1=C(C=CC=N1)C2=NC(N[C@H]3C[C@H](F)CNC3)=NC=C2)C4=C(F)C(F)=C(NS(CC5=CC=CC=C5)(=O)=O)C(F)=C4
Molecular Formula
C27H24F4N6O3S
Molecular Weight
588.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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