G-5758
Product Specifications
CAS Number
2413455-99-7
Target
IRE1|||Liposome
Related Pathways
Metabolism|||Cell Cycle/Checkpoint
Bioactivity
G-5758 is an orally active IRE1? inhibitor with an IC50 of 38 nM for XBP1s. It is used in studies involving multiple myeloma models [KMS-11], demonstrating good tolerance in rats at oral doses up to 500 mg/kg. G-5758 exhibits pharmacodynamic effects comparable to those induced by IRE1 knockdown.
Smiles
O(C1=C(C=CC=N1)C2=NC(N[C@H]3C[C@H](F)CNC3)=NC=C2)C4=C(F)C(F)=C(NS(CC5=CC=CC=C5)(=O)=O)C(F)=C4
Molecular Formula
C27H24F4N6O3S
Molecular Weight
588.58
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
NBP2-54546JF646 0.1 mL
Mouse Monoclonal TOP2A Antibody (TOP2A/1361) [Janelia Fluor 646]
Ask
View Details M2360-02S-ML405 100 µL
MAP Kinase 3 (Mitogen-activated Protein Kinase 3, MAPK 3, Mapk3, ERT2, Extracellular Signal-regulated Kinase 1, ERK1, ERK-1, Esrk1, Insulin-stimulated MAP2 Kinase, MAP Kinase Isoform p44, Microtubule-associated Protein 2 Kinase, Mitogen-activated Protein Kinase 1, MAP Kinase 1, MAPK 1, MAPK1, MNK1, p44, p44erk1, p44-ERK1, p44mapk, p44-MAPK, Prkm3) (MaxLight 405) discontinued
Ask
View Details