DFPQ
Product Specifications
CAS Number
911678-60-9
Bioactivity
DFPQ is a powerful and selective β-arrestin-biased negative allosteric modulator (NAM) targeting the β2-adrenergic receptor. It specifically inhibits the interaction of β-arrestin with β2AR without altering β-agonist-induced cAMP production. Additionally, DFPQ reduces functional desensitization of the β2AR in airway smooth muscle, enhancing β-agonists' capacity to maintain bronchorelaxation and curbing cell migration during prolonged β-agonist treatment.
Smiles
FC1=CC=C(C=C1F)NC=2N=C3C=CC=CC3=C(N2)NC4CCCCC4
Molecular Formula
C20H20F2N4
Molecular Weight
354.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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