DMBA-SIL-Mal-MMAE
Product Specifications
CAS Number
2923885-49-6
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
DMBA-SIL-Mal-MMAE, a cytotoxin-linker conjugate designed for antibody-drug conjugates (ADC), exhibits significant antitumor activity. It incorporates the anti-mitotic agent monomethyl auristatin E (MMAE, a tubulin inhibitor) via the linker DMBA-SIL-Mal [1].
Smiles
[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OC(C(NCCOCCOCCOCCOCCN3C(=O)C=CC3=O)=O)C4=CC=C(NC(OCC5=CC(OC)=CC(OC)=C5)=O)C=C4)=O)C)C(C)C)=O)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
Molecular Formula
C72H106N8O20
Molecular Weight
1403.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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