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Z57346765

Product Specifications

CAS Number

1016340-64-9

Target

Others, PGK1

Related Pathways

Others, Metabolism

Purity

0.9985

Bioactivity

Z57346765 is a specific PGK1 (Phosphoglycerate kinase 1) inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis. In the clinical phase, Z57346765 had a dose-dependent inhibitory effect on locally advanced renal clear cell carcinoma (KIRC) by inducing changes in the expression of genes related to cell metabolism, DNA replication, and the cell cycle.

Smiles

OCCNC=1N=C(N=C2C=CC=CC21)NC3=CC=C(C=C3)C

Molecular Formula

C17H18N4O

Molecular Weight

294.35

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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