Z57346765
Product Specifications
CAS Number
1016340-64-9
Target
Others|||PGK1
Related Pathways
Others|||Metabolism
Purity
0.9985
Bioactivity
Z57346765 is a specific PGK1 (Phosphoglycerate kinase 1) inhibitor that inhibits PGK1-dependent cell proliferation by decreasing the metabolic enzyme activity of PGK1 during glycolysis. In the clinical phase, Z57346765 had a dose-dependent inhibitory effect on locally advanced renal clear cell carcinoma (KIRC) by inducing changes in the expression of genes related to cell metabolism, DNA replication, and the cell cycle.
Smiles
OCCNC=1N=C(N=C2C=CC=CC21)NC3=CC=C(C=C3)C
Molecular Formula
C17H18N4O
Molecular Weight
294.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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