XL44
Product Specifications
CAS Number
2637949-91-6
Target
Apoptosis
Related Pathways
Apoptosis
Bioactivity
XL44, as an hRpn13 binder, triggers hRpn13-dependent apoptosis and limits cell viability via a PCLAF-dependent mechanism. It causes ubiquitin-dependent degradation of hRpn13 Pru and ubiquitin-independent degradation of specific KEN box-containing proteins [1].
Smiles
C(=C1C=2C(NC1=O)=CC=C(F)C2)C3=CC(NC(=O)C4=CC=C(OC)C=C4)=CC=C3
Molecular Formula
C23H17FN2O3
Molecular Weight
388.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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