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WNTinib

Product Specifications

CAS Number

2770091-44-4

Target

Apoptosis|||Wnt/beta-catenin

Related Pathways

Cytoskeletal Signaling|||Apoptosis|||Stem Cells

Bioactivity

WNTinib (APS-8-100-2), a multi-kinase inhibitor, selectively targets ?-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC) and impedes oncogenic Wnt signaling. It achieves this by inhibiting KIT/MAPK and subsequent activation of EZH2 [1].

Smiles

O(C=1C=C(C(NC)=O)N=CC1)C2=CC(F)=C(NC(NC3=CC=C(C(C(F)(F)F)(F)F)C=C3)=O)C=C2

Molecular Formula

C22H16F6N4O3

Molecular Weight

498.38

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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