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Wnt/?-catenin-IN-3

Product Specifications

CAS Number

1809413-98-6

Target

MDM-2/p53|||Wnt/beta-catenin

Related Pathways

Cytoskeletal Signaling|||Apoptosis|||Stem Cells

Bioactivity

Wnt/?-catenin-IN-3 (compound 17), a Wnt/?-catenin inhibitor, exhibits low micromolar GI 50 s across different cancer cell lines. It induces G2/M cell cycle arrest through the activation of the p53-p21 pathway and promotes both intrinsic and extrinsic apoptotic death in colon cancer cells [1].

Smiles

O(C)C1=C2C(OC(=CC2=O)C3=CC(NC(=O)C4=CC=C(OC)C=C4)=CC=C3)=CC(OC)=C1OC

Molecular Formula

C26H23NO7

Molecular Weight

461.46

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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