Wnt/?-catenin-IN-3
Product Specifications
CAS Number
1809413-98-6
Target
MDM-2/p53|||Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling|||Apoptosis|||Stem Cells
Bioactivity
Wnt/?-catenin-IN-3 (compound 17), a Wnt/?-catenin inhibitor, exhibits low micromolar GI 50 s across different cancer cell lines. It induces G2/M cell cycle arrest through the activation of the p53-p21 pathway and promotes both intrinsic and extrinsic apoptotic death in colon cancer cells [1].
Smiles
O(C)C1=C2C(OC(=CC2=O)C3=CC(NC(=O)C4=CC=C(OC)C=C4)=CC=C3)=CC(OC)=C1OC
Molecular Formula
C26H23NO7
Molecular Weight
461.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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