Tuspetinib hydrate
Product Specifications
CAS Number
2758339-04-5
Target
Apoptosis, FLT
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis
Bioactivity
Tuspetinib (HM43239) hydrate is a selectively active FLT3 inhibitor for oral administration, demonstrating IC50 values of 1.1 nM for FLT3 WT, 1.8 nM for FLT3 internal tandem duplication (ITD), and 1.0 nM for FLT3 D835Y kinases. As a reversible type I inhibitor, it suppresses FLT3 kinase activity and influences signaling pathways including p-STAT5, p-ERK, SYK, JAK1/2, and TAK1. Additionally, Tuspetinib hydrate inhibits leukemic cell proliferation and triggers apoptosis [1] [2] [3].
Smiles
ClC=1C(C=2C=3C(NC2)=CC(C)=CC3)=NC(NC4=CC(=CC(CN5C[C@@H](C)N[C@@H](C)C5)=C4)C6CC6)=NC1.O
Molecular Formula
C29H35ClN6O
Molecular Weight
519.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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