TOPOI/PARP-1-IN-1
Product Specifications
CAS Number
2948352-16-5
Target
Topoisomerase|||PARP|||Apoptosis
Related Pathways
Apoptosis|||Chromatin/Epigenetic|||DNA Damage/DNA Repair
Bioactivity
Compound B6, also known as TOPOI/PARP-1-IN-1, is a dual inhibitor targeting TOPOI and PARP, exhibiting low cytotoxicity and oral activity with a PARP1 IC 50 of 0.09 ?M. This compound effectively inhibits cancer cell proliferation and migration, induces cell cycle arrest at the G0/G1 phase, and triggers apoptosis. In murine models, TOPOI/PARP-1-IN-1 demonstrated a tumor growth inhibition rate (TGI) of 75.4% [1].
Smiles
C(CCC=1NC=2C(N1)=CC(Br)=C(Br)C2)[C@@H]3[C@@]4([C@@]5([C@](CN3C(OCC6C=7C(C=8C6=CC=CC8)=CC=CC7)=O)(CCCN5CCC4)[H])[H])[H]
Molecular Formula
C36H38Br2N4O2
Molecular Weight
718.52
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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