TH9619
Product Specifications
CAS Number
2379556-22-4
Target
Antifolate, Cell Cycle Arrest, DHFR
Related Pathways
Metabolism, Cell Cycle/Checkpoint, DNA Damage/DNA Repair
Purity
0.9807
Bioactivity
TH9619 is an effective inhibitor of both dehydrogenase and cyclohydrolase activities in MTHFD1 and MTHFD2 (IC50=47 nM) . It induces folate trapping and cell cycle arrest, thereby selectively killing cancer cells expressing MTHFD2.
Smiles
N(C(CC1=C(N)NC(N)=NC1=O)=O)C=2C=C(F)C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)=NC2
Molecular Formula
C17H18FN7O7
Molecular Weight
451.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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