Soquelitinib
Product Specifications
CAS Number
2226636-04-8
Target
COX, Immunology/Inflammation related, IL Receptor, CXCR, Tyrosine Kinases, TNF
Related Pathways
Neuroscience, Apoptosis, Tyrosine Kinase/Adaptors, GPCR/G Protein, Immunology/Inflammation, Autophagy
Purity
0.9954
Bioactivity
Soquelitinib (CPI-818) is a covalent, irreversible, oral and selective ITK inhibitor that preferentially inhibits Th2 cytokine production over Th1, inhibits in vivo tumor growth in mice, and decreases markers of T-cell exhaustion, resulting in an increase in tumor infiltration and up-regulation of CXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.
Smiles
C(=O)(C1=C(OC)C=C(C)C(SC=2SC(NC(=O)C3CC3)=NC2)=C1)N4C[C@@H](C)N(C(C=C)=O)CCC4
Molecular Formula
C25H30N4O4S2
Molecular Weight
514.66
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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