SIK-IN-1
Product Specifications
CAS Number
3033846-29-3
Target
AMPK
Related Pathways
Chromatin/Epigenetic|||PI3K/Akt/mTOR signaling
Bioactivity
SIK-IN-1 (Compound 53) acts as a potent inhibitor of salt-inducible kinase (SIK), specifically targeting SIK1, SIK2, and SIK3 with IC50 values of 0.1, 0.4, and 1.5 nM, respectively. Additionally, it effectively suppresses TNFa release with an IC50 of 0.5 nM and enhances LPS-induced IL-10 release in human macrophages with an EC50 of 4 nM [1].
Smiles
C(#N)C=1N2C(=CN=C2C=CC1NC)C3=CC(OCC4(N)CCCC4)=C(C#N)C(SC)=C3
Molecular Formula
C23H24N6OS
Molecular Weight
432.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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