PTK7/?-catenin-IN-2
Product Specifications
CAS Number
902434-29-1
Target
Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling|||Stem Cells
Bioactivity
PTK7/?-catenin-IN-2 (compound 04967) acts as an inhibitor targeting both PTK7 and ?-catenin, effectively preventing their interaction with an IC 50 of 5.6 ?M and disrupting the Wnt/?-catenin signaling pathway. This interference supports its role in inhibiting cell growth reliant on Wnt signaling, exhibiting anticancer capabilities. Additionally, the compound displays an inhibitory effect on the binding of p53 to MDM2, with an IC 50 value of 157.1 ?M [1].
Smiles
CC=1N2C(=CC(=N2)C3=CC=C(Cl)C=C3)N=C(C)C1CCC(NCCCN4CCN(CC4)C5=CC(Cl)=CC=C5)=O
Molecular Formula
C30H34Cl2N6O
Molecular Weight
565.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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