PSMA-IN-2

PSMA-IN-2, an inhibitor of PSMA with a K i value of 1.07 nM, exhibits favorable in vivo NIR imaging (? EM = 1088 nm, ? ex = 808 nm) and is useful for NIRII image-guided tumor resection surgery in PSMA-positive tumor-bearing mice [1].

N(CCC(NCCCC[C@H](NC(N[C@@H](CNC=1C(=O)C(=O)C1O)C(O)=O)=O)C(O)=O)=O)(C)C2=CC=C(C=3C=4C(C(=C5C3N=S=N5)C6=CC=C(N(CCC(NCCCC[C@H](NC(N[C@@H](CNC=7C(=O)C(=O)C7O)C(O)=O)=O)C(O)=O)=O)C)C=C6)=NSN4)C=C2