PROTAC TYK2 degrader-1
Product Specifications
CAS Number
2770470-20-5
Target
JAK|||PROTACs
Related Pathways
PROTAC|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Stem Cells|||JAK/STAT signaling|||Angiogenesis
Bioactivity
PROTAC TYK2 degrader-1 (CPD-155) functions as a selective degrader of TYK2, demonstrating a degradation maximum (D max) greater than 60%. This compound effectively targets TYK2 for degradation, utilizing a linker to connect the TYK2 ligand with the VHL ligand Thalidomide, each color-coded for identification.
Smiles
O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCCNC(=O)C=4C=CC(NC5=CC(NC6=C(OC)C(=CC=C6)C=7N=CN(C)N7)=C(C(NC)=O)N=N5)=NC4
Molecular Formula
C40H41N13O7
Molecular Weight
815.84
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Product Datasheet
https://www.targetmol.com/attachment/DataSheet/212216394429759585/T87269
Available Sizes
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