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PROTAC TYK2 degrader-1

Product Specifications

CAS Number

2770470-20-5

Target

JAK|||PROTACs

Related Pathways

PROTAC|||Chromatin/Epigenetic|||Tyrosine Kinase/Adaptors|||Stem Cells|||JAK/STAT signaling|||Angiogenesis

Bioactivity

PROTAC TYK2 degrader-1 (CPD-155) functions as a selective degrader of TYK2, demonstrating a degradation maximum (D max) greater than 60%. This compound effectively targets TYK2 for degradation, utilizing a linker to connect the TYK2 ligand with the VHL ligand Thalidomide, each color-coded for identification.

Smiles

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCCNC(=O)C=4C=CC(NC5=CC(NC6=C(OC)C(=CC=C6)C=7N=CN(C)N7)=C(C(NC)=O)N=N5)=NC4

Molecular Formula

C40H41N13O7

Molecular Weight

815.84

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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