PROTAC SOS1 degrader-5
Product Specifications
CAS Number
2836273-61-9
Target
Ras, PROTACs
Related Pathways
MAPK, PROTAC, GPCR/G Protein
Bioactivity
PROTAC SOS1 degrader-5 (compound 4) serves as an effective degrader of PROTAC SOS1, exhibiting a DC50 of 13 nM. It robustly suppresses the proliferation of NCI-H358 cells, with an IC50 value of 5 nM [1].
Smiles
C(OC1=CC2=C(C=C1OC)N=C(C)N=C2N[C@H](C)C3=CC(C(F)(F)F)=CC(N)=C3)C4(CN(C(CCCCCCNC5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5)=O)C)CC4
Molecular Formula
C45H51F3N8O7
Molecular Weight
872.93
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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