PROTAC KRAS G12C degrader-2
Product Specifications
CAS Number
2378257-72-6
Target
PROTACs|||Ras|||Kras
Related Pathways
GPCR/G Protein|||PROTAC|||MAPK
Bioactivity
PROTAC KRAS G12C degrader-2 (compound 432) acts as a bifunctional modulator, enhancing the hydrolysis of K-Ras protein. One end of this compound features a cereblon inhibitor of apoptosis proteins (IAP), while the other end contains a moiety that binds to KRAS [1].
Smiles
FC=1C2=C(C(=NC(O[C@@H](CN3CCN(CC4CCN(CC4)C=5C=C6C(=CC5)C(=O)N(C6=O)C7C(=O)NC(=O)CC7)CC3)C)=N2)N8CCN(C(C=C)=O)CC8)C=C(Cl)C1C=9C%10=C(C=C(O)C9)C=CC=C%10
Molecular Formula
C51H53ClFN9O7
Molecular Weight
958.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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