PROTAC ERα Degrader-7
Product Specifications
CAS Number
3025781-93-2
Target
PROTACs, Estrogen Receptor/ERR
Related Pathways
Endocrinology/Hormones, PROTAC
Bioactivity
PROTAC ERα Degrader-7 (Compound i-320) is a powerful PROTAC degrader targeting the estrogen receptor alpha (ERα), exhibiting a DC50 of 0.000006 μM. This compound consists of a cereblon-binding segment, LBM, connected to ERBM, an ERα-binding ligand that includes a benzofused partially saturated 6-membered carbocyclic or heterocyclic ring [1].
Smiles
FC1(F)C[C@@H]([C@@H](C=2C1=CC(O)=CC2)C3=CC=C(C=C3)N4CCC(CN5CCN(CC5)C=6C=C7C(=CC6)C(=O)N(C7)[C@@H]8C(=O)NC(=O)CC8)CC4)C9=CC=C(C)C=C9
Molecular Formula
C46H49F2N5O4
Molecular Weight
773.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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