Progranulin modulator-1
Product Specifications
CAS Number
2641013-11-6
Target
Others, TNF
Related Pathways
Apoptosis, Others
Bioactivity
Progranulin Modulator-1 (Compound 60) is an orally active compound that promotes progranulin (PGRN) secretion. It enhances the ability of BV-2 cells to elevate PGRN levels, exhibits low cytotoxicity, and possesses an inhibitory effect on hERG. The EC50 for PGRN is 83 nM, and the IC50 for hERG is 3100 nM [1].
Smiles
FC1=CC=C([C@@H]2N(CCC=3C2=CC=CC3)C4=N[C@@H](CO4)[C@@]5(F)CNC5)C=C1
Molecular Formula
C21H21F2N3O
Molecular Weight
369.41
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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