PP487
Product Specifications
CAS Number
1092787-12-6
Target
EGFR|||mTOR|||c-Met/HGFR|||DNA-PK|||VEGFR|||PI3K|||PDGFR|||Src|||Bcr-Abl
Related Pathways
DNA Damage/DNA Repair|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Angiogenesis|||JAK/STAT signaling|||Tyrosine Kinase/Adaptors
Bioactivity
PP487 is a dual tyrosine kinase/PI (3) K inhibitor, exhibiting IC50 values of 0.017 ?M, 0.072 ?M, 0.004 ?M, 0.01 ?M, 0.55 ?M, 0.22 ?M, and < 0.01 ?M against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].
Smiles
NC1=C2C(=NN(C(C)C)C2=NC=N1)C3=CC(O)=C(Br)C=C3
Molecular Formula
C14H14BrN5O
Molecular Weight
348.2
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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