Pim-1/2 kinase inhibitor 2
Product Specifications
CAS Number
2918764-16-4
Target
Pim
Related Pathways
Chromatin/Epigenetic, JAK/STAT signaling
Bioactivity
Compound 5b, designated as Pim-1/2 kinase inhibitor 2, acts as a competitive inhibitor of both PIM-1 and PIM-2 kinases, demonstrating IC50 values of 1.31 μM and 0.67 μM, respectively. This compound exhibits potent in-vitro anticancer activity against various cancer cell lines, including myeloid leukemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2), while showing low cytotoxicity to the normal human lung fibroblast Wi-38 cell line [1].
Smiles
C(#N)C1=C(C=2C(=NC3=C(C2)C=C(Cl)C=C3)N4CCOCC4)C=C(NC1=O)C5=CC(O)=CC=C5
Molecular Formula
C25H19ClN4O3
Molecular Weight
458.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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