PI3Kα-IN-22
Product Specifications
CAS Number
2925030-26-6
Target
PI3K
Related Pathways
PI3K/Akt/mTOR signaling
Bioactivity
PI3Kα-IN-22 (Compound 17) is a potent, selective, and orally active inhibitor targeting the PI3Kα H1047R mutation, exhibiting an IC 50 of 1 nM in the pAKT T47D AlphaLISA assay. It has demonstrated the ability to induce tumor regressions in the HCC1954 tumor model in mice [1].
Smiles
[C@@H](NC1=C(C(O)=O)C=CC=C1)(C)C=2C=3N(C(=O)C(C#N)=C(N3)N4CCC(F)(F)CC4)C=C(C)C2
Molecular Formula
C24H23F2N5O3
Molecular Weight
467.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
17119116 3x 1.0 µg
Ctsql2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
Sign In for Pricing
View Details 
GTR15082887 1 Vial
Lentiviral human KLRC2 shRNA (UAS) - Lentiviral human KLRC2 shRNA (UAS, iRFP) (100)
Sign In for Pricing
View Details 
26136151 3x 1.0 µg DNA
KRTAP16-1 CRISPR All-in-one AAV vector set (with saCas9)(Human)
Sign In for Pricing
View Details