PI3Kα-IN-22
Product Specifications
CAS Number
2925030-26-6
Target
PI3K
Related Pathways
PI3K/Akt/mTOR signaling
Bioactivity
PI3Kα-IN-22 (Compound 17) is a potent, selective, and orally active inhibitor targeting the PI3Kα H1047R mutation, exhibiting an IC 50 of 1 nM in the pAKT T47D AlphaLISA assay. It has demonstrated the ability to induce tumor regressions in the HCC1954 tumor model in mice [1].
Smiles
[C@@H](NC1=C(C(O)=O)C=CC=C1)(C)C=2C=3N(C(=O)C(C#N)=C(N3)N4CCC(F)(F)CC4)C=C(C)C2
Molecular Formula
C24H23F2N5O3
Molecular Weight
467.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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