PI3K/HDAC-IN-3
Product Specifications
CAS Number
3006905-22-9
Target
PI3K|||HDAC
Related Pathways
DNA Damage/DNA Repair|||Chromatin/Epigenetic|||PI3K/Akt/mTOR signaling
Bioactivity
PI3K/HDAC-IN-3 (36) acts as a dual inhibitor targeting PI3K and HDAC, exhibiting respective IC50 concentrations of 0.23 nM for PI3K? and 172 nM for HDAC1. In MV4-11 cells, it inhibits AKT phosphorylation while enhancing H3 acetylation. Furthermore, PI3K/HDAC-IN-3 (36) demonstrates substantial, dose-dependent anticancer effects in an MV4-11 xenograft model [1].
Smiles
O(CCCCCCC(NC1=C(N)C=CC=C1)=O)C=2C3=C(C=C(C2)C=4C=C(NS(=O)(=O)C5=C(F)C=C(F)C=C5)C(OC)=NC4)C(C)=NC=N3
Molecular Formula
C34H34F2N6O5S
Molecular Weight
676.73
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
253871-ML405 100 µL
ZNF70 (Zinc Finger Protein 70, Cos17, MGC48959) (MaxLight 405) discontinued
Ask
View Details 
QP7974-ec-200ug 200ug
Recombinant Mouse Placenta-expressed transcript 1 protein Protein, His-SUMO, E.coli-200ug
Ask
View Details