PHGDH-IN-5
Product Specifications
CAS Number
17402-86-7
Target
Dehydrogenase
Related Pathways
Metabolism
Bioactivity
Compound B12 (PHGDH-IN-5) acts as a covalent inhibitor of PHGDH, demonstrating an IC50 value of 0.29 μM. It has been shown to inhibit the proliferation of cancer cell lines that overexpress PHGDH and reduce the production of glucose-derived serine in MDA-MB-468 cells [1].
Smiles
N(=O)(=O)C1=C2C(S(=O)(=O)C=C2)=CC=C1
Molecular Formula
C8H5NO4S
Molecular Weight
211.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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