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PHGDH-IN-5

Product Specifications

CAS Number

17402-86-7

Target

Dehydrogenase

Related Pathways

Metabolism

Bioactivity

Compound B12 (PHGDH-IN-5) acts as a covalent inhibitor of PHGDH, demonstrating an IC50 value of 0.29 ?M. It has been shown to inhibit the proliferation of cancer cell lines that overexpress PHGDH and reduce the production of glucose-derived serine in MDA-MB-468 cells [1].

Smiles

N(=O)(=O)C1=C2C(S(=O)(=O)C=C2)=CC=C1

Molecular Formula

C8H5NO4S

Molecular Weight

211.2

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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