PARP1/c-Met-IN-1
Product Specifications
CAS Number
2944101-99-7
Target
C-Met/HGFR, Apoptosis, PARP
Related Pathways
DNA Damage/DNA Repair, Apoptosis, Chromatin/Epigenetic, Tyrosine Kinase/Adaptors
Bioactivity
PARP1/c-Met-IN-1 (Compound 16) serves as a selective dual inhibitor targeting both PARP1 and c-Met, demonstrating IC50 values of 3.3 nM and 32.2 nM, respectively. This compound effectively induces apoptosis and causes cell cycle arrest at the G2/M phase in MDA-MB-231 cells. Furthermore, PARP1/c-Met-IN-1 displays notable antitumor activity in mouse models [1].
Smiles
O(CCN1N=C(C=CC1=O)C=2C=CC=NC2)C=3C4=C(C=C(C=C4)N5CCN(C(=O)C6=CC(CC=7C=8C(C(=O)NN7)=CC=CC8)=CC=C6F)CC5)N=CC3
Molecular Formula
C40H33FN8O4
Molecular Weight
708.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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