Pacritinib citrate
Product Specifications
CAS Number
1228923-42-9
Target
JAK|||FLT
Related Pathways
JAK/STAT signaling|||Angiogenesis|||Stem Cells|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic
Bioactivity
Pacritinib (SB1518) citrate effectively inhibits wild-type JAK2 (IC 50 =23 nM) and the JAK2 V617F mutant (IC 50 =19 nM) . It also targets FLT3 (IC 50 =22 nM) and the FLT3 D835Y mutant (IC 50 =6 nM) . This compound is utilized in the study of acute myeloid leukemia (AML) and myelofibrosis (MF) [1] [2] [3].
Smiles
OC(CC(O)(C(O)=O)CC(O)=O)=O.N1(CCCC1)CCOc2c3cc(Nc4nc(c5cc(COC/C=C/COC3)ccc5)ccn4)cc2
Molecular Formula
C34H40N4O10
Molecular Weight
664.7
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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