Nur77 modulator 3
Product Specifications
CAS Number
2097787-75-0
Target
Autophagy, mTOR
Related Pathways
Autophagy, PI3K/Akt/mTOR signaling
Bioactivity
Nur77 modulator 3 (9e) binds to Nur77 and inhibits TGF-β1-induced α-SMA and COLA1 expression in a Nur77-dependent manner. It induces Nur77 expression and enhances autophagic flux by inhibiting the mTORC1 signaling pathway in vitro and in vivo. Nur77 modulator 3 blocks the progression of hepatic fibrosis [1].
Smiles
C(=N/NC(NC1=CC=C(C)C=C1)=S)\C=2C=3C(NC2)=CC=CC3
Molecular Formula
C17H16N4S
Molecular Weight
308.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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