NSD-IN-3
Product Specifications
CAS Number
744260-15-9
Target
Histone Methyltransferase, Apoptosis
Related Pathways
Chromatin/Epigenetic, Apoptosis
Bioactivity
NSD-IN-3 (compound 3) serves as a potent inhibitor of the nuclear receptor binding SET domain (NSD) . It effectively targets NSD2-SET and NSD3-SET, displaying IC 50 values of 0.81 μM and 0.84 μM, respectively. This compound also impedes the dimethylation of histone H3K36 and suppresses the expression of genes targeted by NSDs in non-small cell lung cancer cells. Furthermore, NSD-IN-3 promotes s-phase cell cycle arrest and induces apoptosis [1].
Smiles
C(COC1=CC=C(Br)C=C1)N2C=3C(N=C2)=C(N)N=CN3
Molecular Formula
C13H12BrN5O
Molecular Weight
334.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb470434 100 µL
Spectrin (alpha + beta) Rabbit Polyclonal Antibody (HRP)
Sign In for Pricing
View Details 