NPD10084
Product Specifications
CAS Number
1040706-91-9
Target
PKM
Related Pathways
Metabolism
Bioactivity
NPD10084 is an inhibitor of pyruvate kinase PKM2 that blocks non-glycolytic signaling in cancer cells by disrupting PKM2's interaction with ?-catenin or STAT3, thus inhibiting downstream pathways. It demonstrates antiproliferative effects against colorectal cancer cells both in vitro and in vivo [1].
Smiles
C(=O)(N1CC=2C=3C(NC2CC1)=CC=CC3)C4=CC=5C(N4)=CC=CC5OC
Molecular Formula
C21H19N3O2
Molecular Weight
345.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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