NLRP3-IN-25
Product Specifications
CAS Number
2660230-90-8
Target
Interleukin, NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Bioactivity
NLRP3-IN-25 (compound 32), an orally available NLRP3 inhibitor, exhibits anti-inflammatory properties by attenuating renal injury in a mouse model of doxorubicin-induced glomerulonephritis and inhibiting IL-1β secretion in THP-1 cells, with an IC 50 value of 21 nM [1].
Smiles
N(C1=CC(C(F)(F)F)=CC=C1C)C2=NC(C(NS(=O)(=O)N3CCCOCC3)=O)=CO2
Molecular Formula
C17H19F3N4O5S
Molecular Weight
448.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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