NIC-12
Product Specifications
CAS Number
2409826-23-7
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Bioactivity
NIC-12, a potent NLRP3 inhibitor, selectively reduces circulating IL-1ß levels in the LPS-endotoxemia mice model and inhibits NLRP3 inflammasome activation in mouse macrophages [1].
Smiles
C(C)(C)C=1N2C3=C(C=C2C(=O)N(CC(N[C@H]4CN(CC5CC5)CCC4)=O)N1)SC(Cl)=C3
Molecular Formula
C22H28ClN5O2S
Molecular Weight
462.01
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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