MTX115325
Product Specifications
CAS Number
2750895-97-5
Target
DUB, Mitophagy
Related Pathways
DNA Damage/DNA Repair, Ubiquitination, Autophagy, Cell Cycle/Checkpoint
Bioactivity
MTX115325 (Example 1) is a brain-penetrant USP30 inhibitor with an IC 50 of 12 nM, administered orally and exhibiting neuroprotective properties. It enhances ubiquitination (EC 50 =32 nM) of TOM20, a mitochondrial outer membrane protein and USP30 substrate, thereby promoting mitophagy. Additionally, MTX115325 prevents dopaminergic neuron loss and maintains striatal dopamine [1].
Smiles
C(=O)(N1[C@@]2([C@@]([C@@H](C)N(C#N)C2)(CC1)[H])[H])C=3OC(=CN3)C=4C=C(C#N)N=CC4
Molecular Formula
C18H16N6O2
Molecular Weight
348.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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