MRK-898
Product Specifications
CAS Number
461450-30-6
Target
GABA Receptor
Related Pathways
Neuroscience, Membrane transporter/Ion channel
Bioactivity
MRK-898, an orally active modulator of the GABA (A) receptor, selectively interacts with the α1, α2, α3, and α5 subunits, displaying K i values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. It is noteworthy that the α1-containing receptors of GABA (A) are classified as "sedative, " whereas receptors containing α2 and/or α3 are designated as "anxiolytic" subtype (s) [1].
Smiles
C(F)(F)(F)C1=NC=2N(C(=CN2)C3=CC(=C(F)C=C3)C4=C(C#N)C=C(F)C=C4)C=C1
Molecular Formula
C20H9F5N4
Molecular Weight
400.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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