MRK-898

MRK-898, an orally active modulator of the GABA (A) receptor, selectively interacts with the α1, α2, α3, and α5 subunits, displaying K i values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. It is noteworthy that the α1-containing receptors of GABA (A) are classified as "sedative, " whereas receptors containing α2 and/or α3 are designated as "anxiolytic" subtype (s) [1].