Calderasib
Product Specifications
CAS Number
2641216-67-1
Target
Kras, Ras
Related Pathways
GPCR/G Protein, MAPK
Purity
0.9869
Bioactivity
Calderasib (MK-1084) is a selective KRAS G12C inhibitor with an IC50 value of 1.2 nM . Calderasib (MK-1084) exhibits significant anticancer activity, and it can be employed either as a monotherapy or in combination with the PD-1 inhibitor Pembrolizumab, providing a versatile approach for the investigation of KRAS-mutant driven cancers.
Smiles
O=C1N2C=3C(C(=N1)N4C(C)CN(C(C=C)=O)C(C)C4)=CC(Cl)=C(N3)C=5C(=C(F)C=CC5F)OCCOC=6C2=C(C(C)C)N=CC6
Molecular Formula
C32H31ClF2N6O4
Molecular Weight
637.08
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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