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MG-1102

Product Specifications

CAS Number

2567913-75-9

Target

MicroRNA, Microtubule Associated

Related Pathways

Chromatin/Epigenetic, Cytoskeletal Signaling

Bioactivity

MG-1102 is a first-in-class dual binder of monomeric tau and pre-miRNA-146a, exhibiting specific inhibition of miRNA146a with IC 50 values of 0.21 mM for double-labeled pre-miRNA146a and 0.36 mM for mono-labeled pre-miRNA146a. It interacts with tau monomers with a K d of 3.21 mM as determined by surface plasmon resonance (SPR), positioning it as a potential multi-target-directed ligand (MTDL) for Alzheimer's disease (AD) [1].

Smiles

C(C=1C(=NNC1)C2=CC3=C(C=C2)C=C(OC)C=C3)N4C(=CC=C4)C5=NC=CS5

Molecular Formula

C22H18N4OS

Molecular Weight

386.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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