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LRRK2-IN-14

Product Specifications

CAS Number

2942328-06-3

Target

LRRK2

Related Pathways

Autophagy

Bioactivity

LRRK2-IN-14 (Compound 8), an orally active inhibitor of LRRK2, exhibits an IC 50 of 6.3 nM against LRRK2 (G2019S) cell activity and demonstrates inhibitory effects on hERG with an IC 50 of 22 μM. Additionally, LRRK2-IN-14 is permeable to the blood-brain barrier [1].

Smiles

O(C)C1=C2NC=3NC(C(C(F)(F)F)=CN3)=NCCCN(C)C(=O)C(=C2)C=C1

Molecular Formula

C17H18F3N5O2

Molecular Weight

381.35

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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