LRRK2-IN-14
Product Specifications
CAS Number
2942328-06-3
Target
LRRK2
Related Pathways
Autophagy
Bioactivity
LRRK2-IN-14 (Compound 8), an orally active inhibitor of LRRK2, exhibits an IC 50 of 6.3 nM against LRRK2 (G2019S) cell activity and demonstrates inhibitory effects on hERG with an IC 50 of 22 ?M. Additionally, LRRK2-IN-14 is permeable to the blood-brain barrier [1].
Smiles
O(C)C1=C2NC=3NC(C(C(F)(F)F)=CN3)=NCCCN(C)C(=O)C(=C2)C=C1
Molecular Formula
C17H18F3N5O2
Molecular Weight
381.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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