LLK203
Product Specifications
CAS Number
2758090-62-7
Target
Apoptosis|||DUB
Related Pathways
Cell Cycle/Checkpoint|||Ubiquitination|||Apoptosis|||DNA Damage/DNA Repair
Bioactivity
LLK203 is a potent dual-target inhibitor of USP2/USP8 with IC50 values of 0.89 ?M and 0.52 ?M, respectively. It promotes ER? degradation and induces apoptosis in breast cancer MCF-7 cells, demonstrating antitumor activity in the 4T1 tumor mice model [1].
Smiles
C(NC1=NC(=CS1)C2=CC=CC=C2)(=O)C3=C(NS(=O)(=O)C4=CC=C(C=C4)C=5SC(C)=CC5)C=C(OC)C=C3
Molecular Formula
C28H23N3O4S3
Molecular Weight
561.69
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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